Glabridin stands out as one of the most bioactive compounds in licorice extract, prized for its scarcity and versatility. Only a very small amount of glabridin can be extracted from 1 ton of licorice roots. its extraction is highly intricate, contributing to its premium status. Unlike many traditional brightening ingredients, glabridin offers a unique combination of efficacy and mildness: it powerfully inhibits melanin production while soothing irritated skin and combating free radicals, making it suitable even for sensitive and delicate skin types.
In cosmetic applications, glabridin excels at addressing multiple skin concerns simultaneously. It targets hyperpigmentation such as sun spots, melasma, and post-acne marks, evens out uneven skin tone, and enhances radiance. Beyond brightening, its anti-inflammatory properties calm redness and sensitivity, while its antioxidant capacity helps delay signs of aging, making it a multi-tasking ingredient that fulfills "brightening + repairing + anti-aging" needs.
Key Functions of Glabridin
Potent Brightening & Spot Reduction: Inhibits tyrosinase activity (a key enzyme in melanin synthesis), reducing melanin production, fading existing spots, and preventing new pigmentation.
Anti-Inflammatory & Soothing: Reduces the release of pro-inflammatory cytokines (e.g., IL-6, TNF-α), alleviating skin redness and sensitivity, and repairing the skin barrier.
Antioxidant & Anti-Aging: Scavenges free radicals, minimizes oxidative damage to the skin, and delays aging signs like fine lines and sagging.
Skin Tone Regulation: Improves uneven skin tone, boosts skin translucency, and promotes a naturally fair and healthy complexion.
Mechanism of Action of Glabridin
Melanin Synthesis Inhibition: Competitively binds to the active site of tyrosinase, directly blocking the formation of melanin precursors (dopaquinone) and preventing pigment accumulation at the source.
Anti-Inflammatory Repair Pathway: Inhibits the NF-κB inflammatory signaling pathway, reducing inflammation-induced pigmentation (e.g., acne marks) and promoting stratum corneum repair to enhance skin resistance.
Antioxidant Protection: Its molecular structure captures and neutralizes free radicals, protecting collagen and elastic fibers from oxidative damage, thus maintaining skin elasticity and firmness.
Benefits and Advantages of Glabridin
Gentle & Safe: Non-cytotoxic with extremely low skin irritation, suitable for all skin types, including sensitive skin and pregnant skin.
Multi-Functional: Combines brightening, anti-inflammatory, and antioxidant effects, enabling comprehensive skincare without the need for multiple ingredients.
High Stability: Resistant to light and heat, maintaining its activity in cosmetic formulations to ensure long-lasting efficacy.
KEY TECHNICAL PARAMETERS
| Appearance |
White powder |
| Purity （HPLC） |
Glabridin≥98% |
| Test of flavone |
Positive |
| Physical characteristics |
|
| Particle-size |
NLT100% 80 Mesh |
| Loss on drying |
≤2.0% |
| Heavy metal |
|
| Total metals |
≤10.0ppm |
| Arsenic |
≤2.0ppm |
| Lead |
≤2.0ppm |
| Mercury |
≤1.0ppm |
| Cadmium |
≤0.5 ppm |
| Microorganism |
|
| Total number of bacteria |
≤100cfu/g |
| Yeast |
≤100cfu/g |
| Escherichia coli |
Not included |
| Salmonella |
Not included |
| Staphylococcus |
Not included |
Applications:
Glabridin is widely used in various high-end skincare products, such as:
Brightening Serums: As a core ingredient, specifically fading spots and enhancing radiance.
Repairing Creams: Combined with moisturizing ingredients to soothe sensitivity and strengthen the skin barrier.
Post-Sun Repair Products: Alleviating UV-induced inflammation and pigmentation.
Luxury Masks: Providing intensive brightening and anti-aging care to improve overall skin quality.
China Glabridin 98% and Herbal Extract PowderGLAGlabridinWhitening Gold
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